Urea → 5,6,7,8-Tetrahydro-4H-oxazolo[4,5-d]azepin-2-ylamine
Reaktionsgleichung
[NH2:1][C:2]([NH2:4])=[O:3].Br.Br[CH:7]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]1=O.[OH-].[Na+]>>[O:3]1[C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=2[N:1]=[C:2]1[NH2:4]Komponenten
4
Reaktionsbedingungen
- Temperatur
- 70 °C
Versuchsvorschrift
6.6 g urea was added to 6 g 5-bromo-azepan-4-one hydrobromide and heated 24 h at 70° C. 4 M aqueous sodium hydroxide was added and the mixture was extracted with chloroform and ethyl acetate. The combined organic layers were evaporated to give 800 mg of the desired product.
Aufarbeitung
- extractionthe mixture was extracted with chloroform and ethyl acetate
- customThe combined organic layers were evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-6af43027edbd42c79986d672e086fb92
- Quelldatensatz
- uspto-grants-2014_06
- Patentnummer
- US08741892B2
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