(3S)-pyrrolidin-3-ol → (S)-1-[5-tert-Butyl-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol

HRID 400895

Reaktionsgleichung

Reaktionsgleichung von HRID 400895
[C:1]([C:5]1[N:6]=[C:7]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[C:8]2[N:13]=[N:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].C(C1N=C(Cl)C2N=NN(CC3C=CC(OC)=CC=3)C=2N=1)(C)(C)C.N1CC[C@H](O)C1>>[C:1]([C:5]1[N:6]=[C:7]([N:23]2[CH2:28][CH2:27][C@H:25]([OH:26])[CH2:24]2)[C:8]2[N:13]=[N:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:9]=2[N:10]=1)([CH3:2])([CH3:3])[CH3:4]

Komponenten

4

Edukt 3

HCID 2733874(3S)-pyrrolidin-3-olHCID 71558051HCID 71558051, VerbindungHCID 866832995-tert-butyl-7-chloro-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

Produkt 1

HCID 86683311(S)-1-[5-tert-Butyl-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol

Versuchsvorschrift

In analogy to the procedure described for the synthesis of 4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine (example 58, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and (S)-pyrrolidin-3-ol and isolated as light-yellow solid. MS (m/e): 383.3 (MH+).

Aufarbeitung

  1. customisolated as light-yellow solid

Quellen und Nachweise

ORD-Eintrag
ord-9f9273e1e8824924966719d817f59d12
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741906B2

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