3,3,4,4-Tetrafluoropyrrolidine Hydrochloride → HCID 86683345, Verbindung

HRID 400935Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 400935
C(C1N=C(N2CCOCC2)C2N=NN(CC3C=CC(OC)=CC=3)C=2N=1)(C)(C)C.[C:29]([C:33]1[N:34]=[C:35](Cl)[C:36]2[N:41]=[N:40][N:39]([CH2:42][C:43]3[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[CH:45][CH:44]=3)[C:37]=2[N:38]=1)([CH3:32])([CH3:31])[CH3:30].Cl.[F:53][C:54]1([F:61])[C:58]([F:60])([F:59])[CH2:57][NH:56][CH2:55]1>>[C:29]([C:33]1[N:34]=[C:35]([N:56]2[CH2:57][C:58]([F:60])([F:59])[C:54]([F:61])([F:53])[CH2:55]2)[C:36]2[N:41]=[N:40][N:39]([CH2:42][C:43]3[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[CH:45][CH:44]=3)[C:37]=2[N:38]=1)([CH3:32])([CH3:31])[CH3:30]

Komponenten

4

Edukt 3

HCID 226459203,3,4,4-Tetrafluoropyrrolidine HydrochlorideHCID 715580514-(5-tert-butyl-3-(4-methoxy benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholineHCID 866832995-tert-butyl-7-chloro-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

Produkt 1

HCID 86683345HCID 86683345, Verbindung

Versuchsvorschrift

In analogy to the procedure described for the synthesis of 4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine (example 58, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 3,3,4,4-tetrafluoropyrrolidine hydrochloride and used without further purification in the consecutive step.

Aufarbeitung

  1. customused without further purification in the consecutive step

Quellen und Nachweise

ORD-Eintrag
ord-f5070ca88c8e4c6285634bcdd5c4188c
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741906B2

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