Oxalic acid--2-oxa-6-azaspiro(3.3)heptane (1/1) → HCID 86683353, Verbindung

HRID 400943

Reaktionsgleichung

Reaktionsgleichung von HRID 400943
[C:1]([C:5]1[N:6]=[C:7]([N:23]2[CH2:28]COC[CH2:24]2)[C:8]2[N:13]=[N:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].C(C1N=C(Cl)C2N=NN(CC3C=[CH:47][C:46]([O:49][CH3:50])=CC=3)C=2N=1)(C)(C)C.C(O)(=O)C(O)=O.C1C2(CNC2)CO1>>[C:1]([C:5]1[N:6]=[C:7]([N:23]2[CH2:24][C:47]3([CH2:46][O:49][CH2:50]3)[CH2:28]2)[C:8]2[N:13]=[N:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:9]=2[N:10]=1)([CH3:3])([CH3:4])[CH3:2]

Komponenten

4

Edukt 3

HCID 53308464Oxalic acid--2-oxa-6-azaspiro(3.3)heptane (1/1)HCID 71558051HCID 71558051, VerbindungHCID 866832995-tert-butyl-7-chloro-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

Produkt 1

HCID 86683353HCID 86683353, Verbindung

Versuchsvorschrift

In analogy to the procedure described for the synthesis of 4-(5-tert-butyl-3-(4-methoxy benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine (example 58, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 2-oxa-6-azaspiro[3.3]heptane oxalate and used without further purification in the consecutive step.

Aufarbeitung

  1. customused without further purification in the consecutive step

Quellen und Nachweise

ORD-Eintrag
ord-89755f9fe4954be5a54121e500cfda76
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741906B2

Verknüpfte Notizen

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