Potassium tert-butoxide → HCID 178441781, Verbindung

HRID 400944Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 400944
[C:1]([C:5]1[N:6]=[C:7]([N:14]2[CH2:17][C:16]([CH2:20][OH:21])([CH2:18]Cl)[CH2:15]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].CC(C)([O-])C.[K+]>C1COCC1>[C:1]([C:5]1[N:6]=[C:7]([N:14]2[CH2:17][C:16]3([CH2:20][O:21][CH2:18]3)[CH2:15]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 23665647Potassium tert-butoxideHCID 178441793HCID 178441793, Verbindung

Produkt 1

HCID 178441781HCID 178441781, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of (1-(5-tert-butyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-3-(chloromethyl)azetidin-3-yl)methanol (284 mg, 915 μmol) (example 179, step 2) and potassium tert-butoxide (205 mg, 1.83 mmol) in THF (3 mL) at 0° C. was stirred to room temperature and stirred for 20 h. The mixture was filtered, concentrated in vacuo and used without further purification in the consecutive step.

Aufarbeitung

  1. stirringstirred for 20 h
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated in vacuo
  4. customused without further purification in the consecutive step

Quellen und Nachweise

ORD-Eintrag
ord-c5e2dfe191b643b4b36a6f33b284d97d
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741906B2

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