HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-Methoxy-N-methylnicotinamide → 2-Phenyl-1-pyridin-3-yl-ethanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N-Methoxy-N-methylnicotinamide | HCID 10558996 | — |
| Edukt | 3,4-Dimethoxy-2-phenylacetophenone | HCID 12336683 | — |
| Edukt | HCID 178418336 | HCID 178418336 | — |
| Produkt | 2-Phenyl-1-pyridin-3-yl-ethanone | HCID 4328900 | 19% |
Reaktionsschritte
Followed the procedure described in Step 2 of Intermediate 7 with N-methoxy-N-methylnicotinamide and benzylmagnesium chloride, where the mixture was stirred for 3 hours. Purification was achieved by column chromatography (PE:EtOAc=5:1) to give Intermediate 31 (110 mg, yield 19%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08741915B2 |
| Quelldatensatz | uspto-grants-2014_06 |
| ORD ID | ord-529c2619fe2a41d1bf2b7619d4df34c9 |
| Quellennotiz | uspto-grants-2014_06 |