(5-Fluoropyridin-3-yl)methanamine → N-((5-Fluoropyridin-3-yl)methyl)-2-isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide
Reaktionsgleichung
[CH:1]([C:4]1[N:5]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[C:6]2[C:11]([C:12]=1[C:13](O)=[O:14])=[CH:10][CH:9]=[C:8]([O:16][CH3:17])[CH:7]=2)([CH3:3])[CH3:2].[F:25][C:26]1[CH:27]=[C:28]([CH2:32][NH2:33])[CH:29]=[N:30][CH:31]=1>>[F:25][C:26]1[CH:27]=[C:28]([CH2:32][NH:33][C:13]([C:12]2[C:11]3[C:6](=[CH:7][C:8]([O:16][CH3:17])=[CH:9][CH:10]=3)[N:5]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[C:4]=2[CH:1]([CH3:2])[CH3:3])=[O:14])[CH:29]=[N:30][CH:31]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 2-isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxylic acid (Compound 139) and (5-fluoropyridin-3-yl)methanamine (Compound 145) by General Procedure C.
Quellen und Nachweise
- ORD-Eintrag
- ord-acb29aa9bd7c4bd68d5a4dca12ea6ad7
- Quelldatensatz
- uspto-grants-2013_09
- Patentnummer
- US08524917B2
Notizen zur Reaktion
Wird geladen…