Nitric Acid → 4-Bromo-3-nitrobenzonitrile

HRID 401397Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 401397
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[N+:10]([O-])([OH:12])=[O:11]>OS(O)(=O)=O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 12162Benzonitrile, 4-bromo-

Produkt 1

HCID 39268614-Bromo-3-nitrobenzonitrileAusbeute 56 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of 4-bromobenzonitrile (4.0 g, 22 mmol) in conc. H2SO4 (10 mL) was added dropwise at 0° C. nitric acid (6 mL). The reaction mixture was stirred at 0° C. for 30 min, and then at room temperature for 2.5 h. The resulting solution was poured into ice-water. The white precipitate was collected via filtration and washed with water until the washings were neutral. The solid was recrystallized from an ethanol/water mixture (1:1, 20 mL) twice to afford 4-bromo-3-nitrobenzonitrile as a white crystalline solid (2.8 g, 56%). 1H NMR (300 MHz, DMSO-d6) δ 8.54 (s, 1H), 8.06 (d, J=8.4 Hz, 1H), 7.99 (d, J=8.4 Hz, 1H); 13C NMR (75 MHz, DMSO-d6) δ 150.4, 137.4, 136.6, 129.6, 119.6, 117.0, 112.6; HPLC ret. time 1.96 min, 10-100% CH3CN, 5 min gradient; ESI-MS 227.1 m/z (MH+).

Aufarbeitung

  1. waitat room temperature for 2.5 h
  2. filtrationThe white precipitate was collected via filtration
  3. washwashed with water until the washings
  4. customThe solid was recrystallized from an ethanol/water mixture (1:1, 20 mL) twice

Quellen und Nachweise

ORD-Eintrag
ord-e6f23ba1ab9647aebb11963682de36cd
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741925B2

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