Sodium Hydroxide → HCID 43566624, Verbindung

HRID 401707Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 401707
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([C:17]([O:19]C)=[O:18])=[CH:16][C:11]=3[N:10]=[CH:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>CCO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:11]=3[N:10]=[CH:9]2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 59625812HCID 59625812, Verbindung

Produkt 1

HCID 43566624HCID 43566624, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 60e (0.18 g, 0.666 mmol) in EtOH (10 mL) was added 1N aqueous NaOH (2.5 mL, 2.5 mmol). The mixture was stirred at room temperature for 4 d. The solvent was evaporated and 1N aqueous HCl was added, followed by extraction with EtOAc. The organic layer was dried over MgSo4 and concentrated. The crude product 60f was purified by preparative reverse phase chromatography. MS m/z (M+H+) 257.1.

Aufarbeitung

  1. customThe solvent was evaporated
  2. addition1N aqueous HCl was added
  3. extractionfollowed by extraction with EtOAc
  4. customThe organic layer was dried over MgSo4
  5. concentrationconcentrated
  6. customThe crude product 60f was purified by preparative reverse phase chromatography

Quellen und Nachweise

ORD-Eintrag
ord-1a92900d899b43e38e5f568ff076ba5c
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741887B2

Notizen zur Reaktion

Wird geladen…