1,4-Dioxane hydrochloride → 6-(2-Fluorobenzyl)-1,4-oxazepan-6-ol Hydrochloride

HRID 401784Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 401784
[F:1][C:2]1[CH:23]=[CH:22][CH:21]=[CH:20][C:3]=1[CH2:4][C:5]1([OH:19])[CH2:11][O:10][CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1.[ClH:24].O1CCOCC1>O1CCOCC1>[ClH:24].[F:1][C:2]1[CH:23]=[CH:22][CH:21]=[CH:20][C:3]=1[CH2:4][C:5]1([OH:19])[CH2:11][O:10][CH2:9][CH2:8][NH:7][CH2:6]1

Komponenten

4

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57731942tert-Butyl 6-(2-fluorobenzyl)-6-hydroxy-1,4-oxazepane-4-carboxylate

Produkt 1

HCID 685346716-(2-Fluorobenzyl)-1,4-oxazepan-6-ol HydrochlorideAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

tert-Butyl 6-(2-fluorobenzyl)-6-hydroxy-1,4-oxazepane-4-carboxylate (Preparation 45, 38 g, 0.12 mol, 1 eq) was dissolved in dioxane (200 mL), and 4M hydrogen chloride/dioxane (60.4 mL, 0.24 mol, 2 eq) was added. The mixture was stirred for 24 h, evaporated, and coevaporated with ether. The formed precipitate was washed with ether and dried to give title compound (29.8 g, 0.11 mol, 95%).

Aufarbeitung

  1. customevaporated
  2. washThe formed precipitate was washed with ether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a8fe73e4a4a64a66ba50205ab1fe4722
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741934B2

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