HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 40181Erstellt: 23. Oktober 2026
Ammonia → 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine
https://huagongshe.com/de/reaction/40181
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Ammonia | HCID 222 | — |
| Edukt | (+-)-2-Butanol | HCID 6568 | — |
| Edukt | (6-(3-Methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanamine | HCID 57691076 | — |
| Edukt | 8-Chloro-3-methoxy-1,5-naphthyridine | HCID 59427340 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | HCID 45487870 | 80% |
Reaktionsschritte
(6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanamine (548 mg, 2225 μmol) and 8-chloro-3-methoxy-1,5-naphthyridine (576 mg, 2959 μmol) were charged in a microwave vial. 2-butanol (7 mL) was added and the reaction mixture was stirred at 120° C. under micro-waves irradiation for 8 h. 2M NH3 in MeOH was added. Purification by MPLC (DCM/MeOH+1% NH4OH: 100/0 to 90/10) afforded the title compound (720 mg, 80% yield). MS m/z=405.1 [M+H]+. Calc'd for C19H16N8OS: 404.46
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08524900B2 |
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| Quelldatensatz | uspto-grants-2013_09 |
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| ORD ID | ord-e067184bd6044a3eb214bfc7983350bf |
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| Quellennotiz | uspto-grants-2013_09 |
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