2-Isopropylpyridine → 1-Oxo-2-(propan-2-yl)-1lambda~5~-pyridine

HRID 402173

Reaktionsgleichung

Reaktionsgleichung von HRID 402173
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)([CH3:3])[CH3:2].C1C=C(Cl)C=C(C(OO)=[O:18])C=1>C(Cl)Cl>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N+:5]=1[O-:18])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 695232-IsopropylpyridineHCID 70297m-Chloroperbenzoic acid

Produkt 1

HCID 131720791-Oxo-2-(propan-2-yl)-1lambda~5~-pyridineAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A mixture of isopropylpyridine (2.1 g, 17.75 mmol) and m-CPBA (5.0 g, 1.3 eq.) in CH2Cl2 was stirred overnight at room temperature. Then, the reaction mixture was diluted with CH2Cl2 (twice the volume) and successively washed with aqueous sodium bicarbonate (twice) and brine, dried (Na2SO4) and evaporated to give 2.0 g (85%) of the title compound 104.

Aufarbeitung

  1. washsuccessively washed with aqueous sodium bicarbonate (twice) and brine
  2. dry with materialdried (Na2SO4)
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-488d8dc885094e2fb161ff668d22dcab
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741926B2

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