3-Chloro-4-fluorobenzaldehyde → 7-Chloro-6-fluoroisoquinoline
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=O.FC1C=C2C(=CC=1)C=[N:17][CH:16]=[CH:15]2>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:7]([CH:15]=[CH:16][N:17]=[CH:5]2)=[CH:8][C:9]=1[F:10]Komponenten
3
Versuchsvorschrift
Starting from 3-chloro-4-fluoro-benzaldehyde, the title compound was prepared by the same reaction sequence as used for the synthesis of 6-fluoro-isoquinoline (3). Rt=0.77 min (Method A). Detected mass: 182.1/184.1 (M+H+).
Quellen und Nachweise
- ORD-Eintrag
- ord-554722bc771344f4936b3cd4c4c91f93
- Quelldatensatz
- uspto-grants-2014_06
- Patentnummer
- US08742116B2
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