Potassium Carbonate → 1118915-78-8

HRID 402753

Reaktionsgleichung

Reaktionsgleichung von HRID 402753
[P:1](Cl)(=[O:18])([O:10]CC1C=CC=CC=1)[O:2]CC1C=CC=CC=1.C([O:27][C:28]1[CH:33]=[C:32]([O:34]COCC)[C:31]([CH:39]([CH3:41])[CH3:40])=[CH:30][C:29]=1[C:42]1[N:46]([C:47]2[CH:48]=[C:49]3[C:53](=[CH:54][CH:55]=2)[N:52]([CH3:56])[CH:51]=[CH:50]3)[C:45](=[O:57])[N:44](C(OCC2C=CC=CC=2)=O)[N:43]=1)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[P:1]([OH:18])([OH:10])([O:34][C:32]1[CH:33]=[C:28]([OH:27])[C:29]([C:42]2[N:46]([C:47]3[CH:48]=[C:49]4[C:53](=[CH:54][CH:55]=3)[N:52]([CH3:56])[CH:51]=[CH:50]4)[C:45](=[O:57])[NH:44][N:43]=2)=[CH:30][C:31]=1[CH:39]([CH3:41])[CH3:40])=[O:2]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 4641201(Chloro(phenylmethoxy)phosphoryl)oxymethylbenzeneHCID 67339760HCID 67339760, Verbindung

Produkt 1

HCID 1355659621118915-78-8

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Dibenzyl phosphorochloridate was added to the solution of benzyl 3-(2-(benzyloxy)-4-(ethoxymethoxy)-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxylate and potassium carbonate in acetone. The reaction mixture was stirred at room temperature overnight. After removal of solvent, the reaction mixture was purified by column chromatography to produce pale yellow oil, which was hydrogenated to give the desired.

Aufarbeitung

  1. customAfter removal of solvent
  2. customthe reaction mixture was purified by column chromatography
  3. customto produce pale yellow oil, which
  4. customto give the

Quellen und Nachweise

ORD-Eintrag
ord-ba3528f8eb2a40c6995f3c6584758949
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08742133B2

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