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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 402821Erstellt: 23. Oktober 2026

4-Chloro-3-(trifluoromethyl)benzaldehyde → 4-{8-[4-Chloro-3-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid

https://huagongshe.com/de/reaction/402821

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt4-Chloro-3-(trifluoromethyl)benzaldehydeHCID 118642—
Edukt4-{2-Oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-ylbenzoic acid hydrochlorideHCID 66764696—
Produkt4-{8-[4-Chloro-3-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acidHCID 86685275—

Reaktionsschritte

The title compound was prepared from 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoic acid hydrochloride salt (20 mg, 0.064 mmol; Example 5-1, Step 4) and 4-chloro-3-trifluoromethylbenzaldehyde (14.68 mg, 0.071 mmol), following essentially the same procedure described in Example 7-1. The title compound was obtained as a white solid (17.4 mg).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08742110B2
Quelldatensatzuspto-grants-2014_06
ORD IDord-2e1a610964984156a708fc3ae721feae
Quellennotizuspto-grants-2014_06