3-Bromo-4-chlorobenzaldehyde → Methyl 4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate

HRID 402823

Reaktionsgleichung

Reaktionsgleichung von HRID 402823
Cl.[O:2]=[C:3]1[N:7]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[CH2:6][C:5]2([CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[O:4]1.[Br:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][C:31]=1[Cl:32])[CH:27]=O>>[Br:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][C:31]=1[Cl:32])[CH2:27][N:20]1[CH2:21][CH2:22][C:5]2([O:4][C:3](=[O:2])[N:7]([C:8]3[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=3)[CH2:6]2)[CH2:18][CH2:19]1

Komponenten

3

Edukt 2

HCID 140498093-Bromo-4-chlorobenzaldehydeHCID 66764605Methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt

Produkt 1

HCID 66764787Methyl 4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate

Versuchsvorschrift

The title compound was prepared from methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt (60 mg, 0.185 mmol; Example 1, Step 2) and 3-bromo-4-chlorobenzaldehyde (48.6 mg, 0.222 mmol) following essentially the same procedure described in Step 1 of Example 7-6. The title compound was obtained as a yellow oil (91 mg) that was used without any further purification.

Quellen und Nachweise

ORD-Eintrag
ord-d9fda3059acb476fa5ff791d7b5c505a
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08742110B2

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