HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,2,3,4-Tetrahydroquinoline → 10-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| Edukt | 4-Fluoro-3-nitrotoluene | HCID 136287 | — |
| Edukt | N-[2-(2,3-dihydro-1H-indol-1-yl)-5-fluorophenyl]-4-methyl-1-piperazine carboxamide maleate | HCID 70406853 | — |
| Produkt | 10-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine | HCID 20129109 | — |
| Produkt | 1-(4-Methyl-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 21297653 | — |
| Produkt | 2-[3,4-Dihydro-1(2H)-quinolinyl]-5-methylaniline | HCID 21297677 | — |
Reaktionsschritte
Starting with 1,2,3,4-tetrahydroquinoline and 2-fluoro-5-methylnitrobenzene and following the steps of 1a to 1f of Example 2, one may obtain, in sequence, 1-(4-methyl-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-amino-4-methylphenyl)-1,2,3,4-tetrahydroquinone, 1-(2-amino-4-methylphenyl)-1,2,3,4-tetrahydroquinoline, N-[2-{1-(5-methylphenyl)-1,2,3,4-tetrahydroquinolin-1-yl}]-4-methyl-1-piperazine carboxamide, and 10-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04723007 |
| Quelldatensatz | uspto-grants-1988_02 |
| ORD ID | ord-50db5f899137486aaab10e21f98eedfe |
| Quellennotiz | uspto-grants-1988_02 |