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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 403466Erstellt: 25. Oktober 2026

Trifluoroacetic acid → {4-[5-(2,5-Difluorophenoxy)-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetic acid

https://huagongshe.com/reaction/403466

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktTrifluoroacetic acidHCID 6422—
Edukttert-Butyl {4-[5-(2,5-difluorophenoxy)-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetateHCID 86679897—
LösungsmittelDichloromethaneHCID 6344—
Produkt{4-[5-(2,5-Difluorophenoxy)-7-propoxyoxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetic acidHCID 53311269114,8%

Reaktionsschritte

69 mg of {4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester were dissolved in 1.6 ml of dichloromethane and treated with 0.8 ml of trifluoroacetic acid. After 16 h the mixture was concentrated and freeze-dried. 71 mg of the title compound were obtained.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08748436B2
Quelldatensatzuspto-grants-2014_06
ORD IDord-3c2e7b54aaa745aeaa2a12e4ded4850f
Quellennotizuspto-grants-2014_06