Trifluoroacetic acid → [4-(5-Cyclopentyloxy-7-propoxy-oxazolo[5,4-d]pyrim idin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid

HRID 403468

Reaktionsgleichung

Reaktionsgleichung von HRID 403468
C([O:5][C:6](=[O:36])[CH2:7][O:8][C:9]1[C:14]([CH3:15])=[CH:13][C:12]([C:16]2[O:17][C:18]3[N:19]=[C:20]([O:29][CH:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)[N:21]=[C:22]([O:25][CH2:26][CH2:27][CH3:28])[C:23]=3[N:24]=2)=[CH:11][C:10]=1[CH3:35])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH:30]1([O:29][C:20]2[N:21]=[C:22]([O:25][CH2:26][CH2:27][CH3:28])[C:23]3[N:24]=[C:16]([C:12]4[CH:13]=[C:14]([CH3:15])[C:9]([O:8][CH2:7][C:6]([OH:36])=[O:5])=[C:10]([CH3:35])[CH:11]=4)[O:17][C:18]=3[N:19]=2)[CH2:31][CH2:32][CH2:33][CH2:34]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86679898[4-(5-Cyclopentyloxy-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid tert-butyl ester

Produkt 1

HCID 53311353[4-(5-Cyclopentyloxy-7-propoxy-oxazolo[5,4-d]pyrim idin-2-yl)-2,6-dimethyl-phenoxy]-acetic acidAusbeute 108,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

25 mg of [4-(5-cyclopentyloxy-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid tert-butyl ester were dissolved in 2 ml of dichloromethane and treated with 1 nil of trifluoroacetic acid. After 16 h the mixture was concentrated and freeze-dried. 24 mg of the title compound were obtained.

Aufarbeitung

  1. concentrationAfter 16 h the mixture was concentrated
  2. customfreeze-dried

Quellen und Nachweise

ORD-Eintrag
ord-f0a4d15b90d148558f23dcb0955982f0
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748436B2

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