Benzenamine, 3-ethynyl- → 4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate Hydrochloride

HRID 403663Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 403663
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[Cl:17])(=[O:3])[CH3:2].[C:18]([C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23])#[CH:19]>C(Cl)(Cl)Cl>[ClH:17].[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[NH:23][C:22]1[CH:24]=[CH:25][CH:26]=[C:20]([C:18]#[CH:19])[CH:21]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 104682Benzenamine, 3-ethynyl-HCID 220221604-Chloro-7-methoxyquinazolin-6-yl acetate

Produkt 1

HCID 866599184-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate HydrochlorideAusbeute 89,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of 4-chloro-7-methoxyquinazolin-6-yl acetate (7.75 g, 0.0307 mol), 3-ethynyl aniline (4 g, 0.0342 mol, 1.11 equiv) and chloroform (120 ml) was refluxed overnight. The reaction mixture was cooled to room temperature and the solution was filtered to give 10.2 g product. MS (ESI) m/z: 334 (M+1).

Aufarbeitung

  1. temperaturewas refluxed overnight
  2. filtrationthe solution was filtered

Quellen und Nachweise

ORD-Eintrag
ord-8f3681ffb6ad484ea8cae4a59c2ee67d
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748453B2

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