Ammonia → 4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-ol

HRID 403664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 403664
Cl.C([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[N:12]=[CH:11][N:10]=[C:9]2[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]#[CH:26])[CH:20]=1)(=O)C.N>CO>[C:25]([C:21]1[CH:20]=[C:19]([NH:18][C:9]2[C:8]3[C:13](=[CH:14][C:15]([O:16][CH3:17])=[C:6]([OH:5])[CH:7]=3)[N:12]=[CH:11][N:10]=2)[CH:24]=[CH:23][CH:22]=1)#[CH:26]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 866599184-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate Hydrochloride

Produkt 1

HCID 219252124-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-olAusbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride (10 g, 0.027 mol), methanol (250 ml) and 25% aqueous ammonia (8 ml, 0.106 mol, 3.93 equiv) was stirred at room temperature for 17 hours and then heated to reflux for 1.5 hours. The mixture was cooled and the precipitate was formed and isolated and dried to give 5.66 g product. MS (ESI) m/z: 307 (M+1).

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux for 1.5 hours
  3. temperatureThe mixture was cooled
  4. customthe precipitate was formed
  5. customisolated
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2c03765ed6134140a1c048dfeb4a9b7d
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748453B2

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