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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 403746Erstellt: 24. Oktober 2026

3-Chlorophenyl isothiocyanate → (S)-Methyl 2-(6-(4-(3-(4-chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

https://huagongshe.com/de/reaction/403746

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt3-Chlorophenyl isothiocyanateHCID 75449—
Edukt(S)-Methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 53303391—
Edukt(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441—
Produkt(S)-Methyl 2-(6-(4-(3-(4-chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731454—

Reaktionsschritte

The compound of example 63 was prepared analogous to compound of example 51 by reaction of compound of example 6 with 3-chlorophenyl isothiocyanate. The compound of example 63 was used directly without isolation for the preparation of compound of example 64.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08748426B2
Quelldatensatzuspto-grants-2014_06
ORD IDord-48e48e66a0234cb0b2ed71aa555f79db
Quellennotizuspto-grants-2014_06