2,4-Difluorobenzoyl chloride → (S)-Methyl 2-(6-(4-(2,4-difluorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403781

Reaktionsgleichung

Reaktionsgleichung von HRID 403781
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C@@H:51]([CH:56]([CH3:58])[CH3:57])[C:52]([O:54][CH3:55])=[O:53])[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.[F:59][C:60]1[CH:68]=[C:67]([F:69])[CH:66]=[CH:65][C:61]=1[C:62](Cl)=[O:63]>>[F:59][C:60]1[CH:68]=[C:67]([F:69])[CH:66]=[CH:65][C:61]=1[C:62]([NH:34][C:35]1[CH:36]=[CH:37][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C@@H:51]([CH:56]([CH3:58])[CH3:57])[C:52]([O:54][CH3:55])=[O:53])[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:39][CH:40]=1)=[O:63]

Komponenten

4

Edukt 3

HCID 5880812,4-Difluorobenzoyl chlorideHCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Produkt 1

HCID 53303632(S)-Methyl 2-(6-(4-(2,4-difluorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Versuchsvorschrift

The compound of example 109 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 2,4-difluorobenzoyl chloride. The compound of example 109 was used directly without isolation for the preparation of compound of example 110.

Quellen und Nachweise

ORD-Eintrag
ord-b873271d7a844adf96282dbb7001b31d
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748426B2

Verknüpfte Notizen

Wird geladen…