4-Methylbenzoyl Chloride → (S)-Methyl 3-methyl-2-(6-(4-(4-methylbenzamido)phenyl)-1-oxoisoindolin-2-yl)butanoate

HRID 403783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 403783
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N[C:35]1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.CC1C=CC(C(Cl)=O)=CC=1.FC1C=C(F)C=CC=1C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)=O>>[CH3:32][CH:31]([CH3:33])[C@H:26]([N:21]1[CH2:20][C:19]2[C:23](=[CH:24][C:16]([C:13]3[CH:12]=[CH:11][C:10]([NH:9][C:1](=[O:8])[C:2]4[CH:3]=[CH:4][C:5]([CH3:35])=[CH:6][CH:7]=4)=[CH:15][CH:14]=3)=[CH:17][CH:18]=2)[C:22]1=[O:25])[C:27]([O:29][CH3:30])=[O:28]

Komponenten

5

Edukt 4

HCID 134054-Methylbenzoyl ChlorideHCID 67307333(S)-2-(6-(4-(2,4-Difluorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acidHCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Produkt 1

HCID 131731469(S)-Methyl 3-methyl-2-(6-(4-(4-methylbenzamido)phenyl)-1-oxoisoindolin-2-yl)butanoate

Versuchsvorschrift

The compound of example 111 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 4-methylbenzoyl chloride. The compound of example 111 was used directly without isolation for the preparation of compound of example 110.

Quellen und Nachweise

ORD-Eintrag
ord-ec6db23f95a14a14bdfd0c228c130d9d
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748426B2

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