4-Fluoro-3-(trifluoromethyl)benzoyl Chloride → (S)-Methyl 2-(6-(4-(4-fluoro-3-(trifluoromethyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-Fluoro-3-(trifluoromethyl)benzoyl Chloride	HCID 144253	—
Edukt	(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate	HCID 123625862	—
Edukt	(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate	HCID 131731441	—
Produkt	(S)-Methyl 2-(6-(4-(4-fluoro-3-(trifluoromethyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate	HCID 131731496	74%

Reaktionsschritte

The compound of example 205 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 4-fluoro-3-trifluoromethyl benzoyl chloride.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08748426B2
Quelldatensatz	uspto-grants-2014_06
ORD ID	ord-88990ebf87fc49c7839a253032aa919f
Quellennotiz	uspto-grants-2014_06