HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Chlorophenyl isothiocyanate → (S)-Methyl 2-(5-(4-(3-(3-chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Chlorophenyl isothiocyanate | HCID 75449 | — |
| Edukt | (S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731499 | — |
| Edukt | (S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731509 | — |
| Produkt | (S)-Methyl 2-(5-(4-(3-(3-chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731513 | — |
Reaktionsschritte
The compound of example 266 was prepared analogous to compound of example 256 by reaction of compound of example 223 with 3-chlorophenyl isothiocyanate. The compound of example 266 was used directly without isolation for the preparation of compound of example 267.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08748426B2 |
| Quelldatensatz | uspto-grants-2014_06 |
| ORD ID | ord-b3346d5b7e0944819d8f06e5da2c85b4 |
| Quellennotiz | uspto-grants-2014_06 |