2-Methoxyphenyl Isothiocyanate → HCID 131731518, Verbindung

HRID 403905

Reaktionsgleichung

Reaktionsgleichung von HRID 403905
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[S:35])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[C:22](=[O:26])[N:21]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[CH2:20]3)=[CH:13][CH:12]=1.NC1C=CC(C2C=C3C(=CC=2)[C:48](=[O:52])N([C@@H](C(C)C)C(OC)=O)C3)=CC=1.COC1C=CC=CC=1N=C=S>>[CH3:48][O:52][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[S:35])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[C:22](=[O:26])[N:21]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[CH2:20]3)=[CH:13][CH:12]=1

Komponenten

4

Edukt 3

HCID 5205992-Methoxyphenyl IsothiocyanateHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731509(S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Produkt 1

HCID 131731518HCID 131731518, Verbindung

Versuchsvorschrift

The compound of example 280 was prepared analogous to compound of example 256 by reaction of compound of example 223 with 2-methoxyphenyl isothiocyanate. The compound of example 280 was used directly without isolation, for the preparation of compound of example 281.

Quellen und Nachweise

ORD-Eintrag
ord-6ca4c845a60041ada07382d456a88918
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748426B2

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