1-Isothiocyanato-3-(trifluoromethyl)benzene → (S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoate

HRID 403907

Reaktionsgleichung

Reaktionsgleichung von HRID 403907
FC1C=CC=CC=1NC(=S)NC1C=CC(C2C=C3C(=CC=2)C(=O)N([C@@H](C(C)C)C(OC)=O)C3)=CC=1.[NH2:36][C:37]1[CH:42]=[CH:41][C:40]([C:43]2[CH:44]=[C:45]3[C:49](=[CH:50][CH:51]=2)[C:48](=[O:52])[N:47]([C@@H:53]([CH:58]([CH3:60])[CH3:59])[C:54]([O:56][CH3:57])=[O:55])[CH2:46]3)=[CH:39][CH:38]=1.[F:61][C:62]([F:73])([F:72])[C:63]1[CH:64]=[C:65]([N:69]=[C:70]=[S:71])[CH:66]=[CH:67][CH:68]=1>>[CH3:59][CH:58]([CH3:60])[C@H:53]([N:47]1[CH2:46][C:45]2[C:49](=[CH:50][CH:51]=[C:43]([C:40]3[CH:41]=[CH:42][C:37]([NH:36][C:70]([NH:69][C:65]4[CH:66]=[CH:67][CH:68]=[C:63]([C:62]([F:61])([F:72])[F:73])[CH:64]=4)=[S:71])=[CH:38][CH:39]=3)[CH:44]=2)[C:48]1=[O:52])[C:54]([O:56][CH3:57])=[O:55]

Komponenten

4

Edukt 3

HCID 1372321-Isothiocyanato-3-(trifluoromethyl)benzeneHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731509(S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Produkt 1

HCID 131731519(S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoate

Versuchsvorschrift

The compound of example 282 was prepared analogous to compound of example 256 by reaction of compound of example 223 with 3-trifluoromethyl phenyl isothiocyanate. The compound of example 282 was used directly without isolation, for the preparation of compound of example 283.

Quellen und Nachweise

ORD-Eintrag
ord-13098a6ac51748879d41339d34e3d28f
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748426B2

Verknüpfte Notizen

Wird geladen…