(R)-3-Methyl-2-(1-oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)iso indolin-2-yl)butanoic acid → 2-Methyl-2-(1-oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)propanoic acid
Reaktionsgleichung
CC(C)[C@@H](N1CC2C(=CC(C3C=CC(NC(NC4C=CC=C(C(F)(F)F)C=4)=O)=CC=3)=CC=2)C1=O)C(O)=O.[CH3:38][C:39]([N:45]1[CH2:53][C:52]2[C:47](=[CH:48][C:49]([C:54]3[CH:59]=[CH:58][C:57]([NH:60][C:61]([NH:63][C:64]4[CH:69]=[CH:68][CH:67]=[C:66]([C:70]([F:73])([F:72])[F:71])[CH:65]=4)=[O:62])=[CH:56][CH:55]=3)=[CH:50][CH:51]=2)[C:46]1=[O:74])([CH3:44])[C:40]([O:42]C)=[O:41]>>[CH3:44][C:39]([N:45]1[CH2:53][C:52]2[C:47](=[CH:48][C:49]([C:54]3[CH:59]=[CH:58][C:57]([NH:60][C:61]([NH:63][C:64]4[CH:69]=[CH:68][CH:67]=[C:66]([C:70]([F:72])([F:73])[F:71])[CH:65]=4)=[O:62])=[CH:56][CH:55]=3)=[CH:50][CH:51]=2)[C:46]1=[O:74])([CH3:38])[C:40]([OH:42])=[O:41]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The compound of example 340 was prepared analogous to compound of example 331 by hydrolysis of the compound of example 339.