Alanine methyl ester hydrochloride → (S)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)propanoate

HRID 403960

Reaktionsgleichung

Reaktionsgleichung von HRID 403960
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@H:12]([CH:17](C)C)[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2.BrC1C=CC(C(OC)=O)=C(CBr)C=1.Cl.COC(=O)[C@H](C)N>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@@H:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2

Komponenten

4

Edukt 3

HCID 2733257Alanine methyl ester hydrochlorideHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Produkt 1

HCID 131731537(S)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)propanoate

Versuchsvorschrift

The compound of example 365 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and alanine methyl ester hydrochloride.

Quellen und Nachweise

ORD-Eintrag
ord-b9f5814b6d2345f185e617cff9c4cf2f
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748426B2

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