(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-3-Methyl-2-(6-(5-(5-methyl-2-phenyloxazole-4-carboxamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)butanoic acid
Reaktionsgleichung
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][CH:34]([CH3:71])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56]([C:58]4[N:59]=[C:60]([C:64]5[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=5)[O:61][C:62]=4[CH3:63])=[O:57])=[CH:51][N:50]=3)=[CH:45][CH:46]=2)[C:41]1=[O:70])[C:36]([O:38]C)=[O:37]>>[CH3:33][CH:34]([CH3:71])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56]([C:58]4[N:59]=[C:60]([C:64]5[CH:65]=[CH:66][CH:67]=[CH:68][CH:69]=5)[O:61][C:62]=4[CH3:63])=[O:57])=[CH:51][N:50]=3)=[CH:45][CH:46]=2)[C:41]1=[O:70])[C:36]([OH:38])=[O:37]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The compound of example 655 was prepared analogous to the compound of example 98 by hydrolysis of compound of example 654.