Piperazine → HCID 178420794, Verbindung

HRID 404611

Reaktionsgleichung

Reaktionsgleichung von HRID 404611
[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>CC(C)=O>[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 178488147HCID 178488147, Verbindung

Produkt 1

HCID 178420794HCID 178420794, VerbindungAusbeute 65,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Esomeprazole (28 gm) was added to acetone (140 ml) and piperazine (8 gm) at room temperature. The reaction mixture was stirred for 1 hour at room temperature and the solid was separated. The separated solid was cooled to 10 to 15° C. and maintained for 1 hour at 10 to 15° C., filtered. The solid obtained was washed with chilled acetone and dried at 40 to 45° C. under vacuum to obtain 23 gm of esomeprazole piperazine salt.

Aufarbeitung

  1. customthe solid was separated
  2. temperatureThe separated solid was cooled to 10 to 15° C.
  3. temperaturemaintained for 1 hour at 10 to 15° C.
  4. filtrationfiltered
  5. customThe solid obtained
  6. washwas washed with chilled acetone
  7. customdried at 40 to 45° C. under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-57f9deacc5d44b7e96c86a75a013f56c
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748619B2

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