Hydrochloric Acid → 2-(3-Fluorophenyl)-2-(piperidin-1-yl)acetic acid hydrochloride

HRID 404669Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 404669
[F:1][C:2]1[CH:3]=[C:4]([CH:8]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:9]([O:11]C)=[O:10])[CH:5]=[CH:6][CH:7]=1.[ClH:19]>O1CCOCC1>[ClH:19].[F:1][C:2]1[CH:3]=[C:4]([CH:8]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86688930Methyl 2-(3-fluorophenyl)-2-(piperidin-1-yl)acetate

Produkt 1

HCID 866889312-(3-Fluorophenyl)-2-(piperidin-1-yl)acetic acid hydrochlorideAusbeute 94,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Methyl 2-(3-fluorophenyl)-2-(piperidin-1-yl)acetate (224 mg, 0.89 mmol) and 37% HCl (813 μl, 26.7 mmol) were dissolved in dioxane (3 ml) and stirred under microwave irradiation at 100° C. for 6 hours. The solvents were evaporated and the residue was triturated with Et2O and sonicated. The solid was collected by suction filtration, washed with Et2O and dried under vacuum overnight to collect 2-(3-fluorophenyl)-2-(piperidin-1-yl)acetic acid hydrochloride (230 mg, 94% yield).

Aufarbeitung

  1. customThe solvents were evaporated
  2. customthe residue was triturated with Et2O
  3. customsonicated
  4. filtrationThe solid was collected by suction filtration
  5. washwashed with Et2O
  6. customdried under vacuum overnight

Quellen und Nachweise

ORD-Eintrag
ord-263c0e04661f4e858ee47c95b16cd8cc
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748613B2

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