Piperidine → 2-(4-Chlorophenyl)-2-(piperidin-1-YL)acetic acid

HRID 404678Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 404678
Br[CH:2]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>C(#N)C>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([CH:2]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:3]([OH:5])=[O:4])=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 10490868alpha-Bromo-4-chlorophenylacetic acid

Produkt 1

HCID 162439412-(4-Chlorophenyl)-2-(piperidin-1-YL)acetic acidAusbeute 62,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

2-Bromo-2-(4-chlorophenyl)acetic acid (300 mg, 1.20 mmol), piperidine (125 μl, 1.26 mmol) and TEA (503 μl, 3.61 mmol) were dissolved in acetonitrile (6 ml). The resulting reaction was stirred at room temperature for 48 hours. Acetonitrile was evaporated, the residue was triturated with acetonitrile/petroleum ether (9/1) and filtered by suction filtration to collect 2-(4-chlorophenyl)-2-(piperidin-1-yl)acetic acid (190 mg, 62.3% yield) as a white solid.

Aufarbeitung

  1. customThe resulting reaction
  2. customAcetonitrile was evaporated
  3. customthe residue was triturated with acetonitrile/petroleum ether (9/1)
  4. filtrationfiltered by suction filtration

Quellen und Nachweise

ORD-Eintrag
ord-5b67af9bf40c45e49f31644160a14fbd
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748613B2

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