Iodomethyl pivalate → 3-[4-(2,2-Dimethyl-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-ylmethoxy)phenyl]hex-4-ynoic acid

HRID 40489

Reaktionsgleichung

Reaktionsgleichung von HRID 40489
[CH3:1][C:2]1([CH3:13])[C:7](=[O:8])[NH:6][C:5]2[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=2[O:3]1.[C:14](OCI)(=O)C(C)(C)C.[OH:23][C:24]1[CH:29]=[CH:28][C:27]([CH:30]([C:36]#[C:37][CH3:38])[CH2:31][C:32]([O:34]C)=[O:33])=[CH:26][CH:25]=1>>[CH3:1][C:2]1([CH3:13])[C:7](=[O:8])[N:6]([CH2:14][O:23][C:24]2[CH:29]=[CH:28][C:27]([CH:30]([C:36]#[C:37][CH3:38])[CH2:31][C:32]([OH:34])=[O:33])=[CH:26][CH:25]=2)[C:5]2[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=2[O:3]1

Komponenten

4

Edukt 3

HCID 104401Iodomethyl pivalateHCID 106073952,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-oneHCID 57835749Methyl 3-(4-hydroxyphenyl)hex-4-ynoate

Produkt 1

HCID 547670753-[4-(2,2-Dimethyl-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-ylmethoxy)phenyl]hex-4-ynoic acid

Versuchsvorschrift

Analogously to example 6, 2,2-dimethyl-4H-benzo[1,4]oxazin-3-one, iodomethyl pivalate and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-[4-(2,2-dimethyl-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-ylmethoxy)phenyl]hex-4-ynoic acid.

Quellen und Nachweise

ORD-Eintrag
ord-861a1ed39991417e9ddff172b478fe57
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530413B2

Verknüpfte Notizen

Wird geladen…