Water → 2,2',4'-Trichloro-[1,1'-biphenyl]-4-amine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Water	HCID 962	—
Edukt	Potassium Carbonate	HCID 11430	—
Edukt	4-Bromo-3-chloroaniline	HCID 88888	—
Edukt	(2,4-Dichlorophenyl)boronic acid	HCID 2734659	—
Katalysator	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
Lösungsmittel	Ethyl Acetate	HCID 8857	—
Lösungsmittel	1,4-Dioxane	HCID 31275	—
Produkt	2,2',4'-Trichloro-[1,1'-biphenyl]-4-amine	HCID 86674250	—

Reaktionsschritte

4-Bromo-3-chloroaniline (3.0 g, 14.5 mmol), (2,4-dichlorophenyl)boronic acid (3.6 g, 18.9 mmol), Pd(dppf)Cl2 (1.2 g, 1.5 mmol), and K2CO3 (4.0 g, 29.1 mmol) were dissolved in 1,4-dioxane (60 mL) and water (15 mL) and the resulting mixture was heated to 80° C. After 16 h the resulting mixture was cooled to room temperature, diluted with EtOAc, washed with water and brine, dried (Na2SO4), and dry packed onto silica gel. Column chromatography yielded the title compound.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08748624B2
Quelldatensatz	uspto-grants-2014_06
ORD ID	ord-a2084d23390e431ba692966ddb144432
Quellennotiz	uspto-grants-2014_06