HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,2-Dichloroethane → 2-bromo-N-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-methylbenzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,2-Dichloroethane | HCID 11 | — |
| Edukt | 4-Amino-4'-chlorodiphenyl | HCID 8675 | — |
| Edukt | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 2-Bromo-4-methylbenzoic acid | HCID 226292 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-bromo-N-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-methylbenzamide | HCID 71060083 | — |
Reaktionsschritte
4′-chloro-[1,1′-biphenyl]-4-amine (159 mg, 0.78 mmol), 2-bromo-4-methylbenzoic acid (140 mg, 0.65 mmol), EDC (125 mg, 0.65 mmol), HOBt (100 mg, 0.65 mmol), and diisopropylethyl amine (0.22 mL, 1.30 mmol) were dissolved in THF (2.6 mL) and stirred at room temperature. After 3 h the resulting mixture directly purified via column chromatography to yield the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08748624B2 |
| Quelldatensatz | uspto-grants-2014_06 |
| ORD ID | ord-5c7d59f64ce94b76a6e62c06cf8ab6b8 |
| Quellennotiz | uspto-grants-2014_06 |