Potassium Carbonate → HCID 71060074, Verbindung

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Reaktionsgleichung

Br[C:2]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)=[O:5].CC1(C)C(C)(C)OB([C:33]2[CH:34]=[CH:35][C:36]([C:39]([NH:41][CH2:42][CH2:43][C:44]([O:46][CH2:47][CH3:48])=[O:45])=[O:40])=[N:37][CH:38]=2)O1.C([O-])([O-])=O.[K+].[K+]>O1CCOCC1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:10]2[CH:11]=[CH:12][C:7]([NH:6][C:4]([C:3]3[CH:20]=[CH:21][C:22]([CH3:24])=[CH:23][C:2]=3[C:33]3[CH:34]=[CH:35][C:36]([C:39]([NH:41][CH2:42][CH2:43][C:44]([O:46][CH2:47][CH3:48])=[O:45])=[O:40])=[N:37][CH:38]=3)=[O:5])=[CH:8][CH:9]=2)=[CH:14][CH:15]=1

Komponenten

Reaktionsbedingungen

Temperatur: 85 °C

Versuchsvorschrift

2-bromo-N-(4′-chloro-[1,1′-biphenyl]-4-yl)-4-methylbenzamide (50 mg, 0.13 mmol), ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate (68 g, 0.16 mmol), Pd(dppf)Cl2 (9 mg, 0.01 mmol), and 2M aqueous K2CO3 (0.13 mL g, 0.25 mmol) were dissolved in 1,4-dioxane (2 mL) and the resulting mixture was heated to 85° C. After 16 h the resulting mixture was cooled to room temperature and purified directly via column chromatography to yield the title compound.

Aufarbeitung

temperatureAfter 16 h the resulting mixture was cooled to room temperature
custompurified directly via column chromatography

Quellen und Nachweise

ORD-Eintrag: ord-3d9e502c645b4889a19aaf553fe4cc55
Quelldatensatz: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08748624B2

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