HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 405243Erstellt: 24. Oktober 2026
Sodium Carbonate → 2-Chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine
https://huagongshe.com/de/reaction/405243
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 4-Bromo-3-chloroaniline | HCID 88888 | — |
| Edukt | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Katalysator | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 2-Chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine | HCID 68834284 | — |
Reaktionsschritte
4-bromo-3-chloroaniline (2.1 g, 10.2 mmol), (4-(trifluoromethyl)phenyl)boronic acid (2.7 g, 14.2 mmol), Pd(dppf)Cl2 (744 mg, 1.0 mmol), 2M aqueous Na2CO3 (15.3 mL, 30.5 mmol) were dissolved in 1,4-dioxane (30 mL) and the resulting mixture was heated to 90° C. After 16 h the resulting mixture was cooled to room temperature, was diluted with EtOAc, washed with water and brine. The organic layer was dried (Na2SO4), concentrated and diethyl ether was added. The resulting precipitate was filtered and dried in vacuo to yield the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08748624B2 |
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| Quelldatensatz | uspto-grants-2014_06 |
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| ORD ID | ord-d72259e8bf7c48729e74a335ef3854e4 |
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| Quellennotiz | uspto-grants-2014_06 |
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