HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonia → Hydroxyamfetamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonia | HCID 222 | — |
| Edukt | 4-Hydroxyphenylacetone | HCID 7019274 | — |
| Edukt | HCID 178418361 | HCID 178418361 | — |
| Katalysator | Nickel | HCID 935 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | Hydroxyamfetamine | HCID 3651 | — |
Reaktionsschritte
A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08530460B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-cb14c09e723444f6967e7938a6ec22f0 |
| Quellennotiz | uspto-grants-2013_09 |