Ammonia → Hydroxyamfetamine

HRID 40556

Reaktionsgleichung

Reaktionsgleichung von HRID 40556
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=O)[CH3:10])=[CH:4][CH:3]=1.[NH3:12].[H][H]>CO.[Ni]>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH2:12])[CH3:10])=[CH:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 222AmmoniaHCID 70192744-HydroxyphenylacetoneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 3651Hydroxyamfetamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).

Aufarbeitung

  1. customAfter complete reaction
  2. filtrationthe mixture is filtrated
  3. customthe solvent is removed in vacuo
  4. customthe crude product is purified by HPLC (MeOH/H2O/NH3)

Quellen und Nachweise

ORD-Eintrag
ord-cb14c09e723444f6967e7938a6ec22f0
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530460B2

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