Sodium Hydroxide → HCID 18365331, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].[N:10]1(C(OC(C)(C)C)=O)[CH2:15][CH2:14][CH:13]([C:16]([O-])=O)[CH2:12][CH2:11]1.[OH-].[Na+]>>[F:8][C:6]1[CH:5]=[CH:4][C:3]2[O:9][C:16]([CH:13]3[CH2:14][CH2:15][NH:10][CH2:11][CH2:12]3)=[N:1][C:2]=2[CH:7]=1Komponenten
4
Versuchsvorschrift
500 mg 2-amino-4-fluorophenol and 900 mg mono-tert-butyl piperidine-1,4-dicarboxylate are heated in 5 g polyphosphoric acid at 200° C. for 4 h. After cooling the reaction mixture is combined with ice water and made basic with 50% NaOH solution. The precipitate is suction filtered, washed with water and dried. 290 mg (V-8) are obtained as a solid.
Aufarbeitung
- temperatureAfter cooling the reaction mixture
- filtrationfiltered