Phenyl pyrimidin-2-ylcarbamate → 4-Quinolin-3-ylmethyl-piperazine-1-carboxylic acid pyrimidin-2-ylamide

HRID 40594

Reaktionsgleichung

Reaktionsgleichung von HRID 40594
C1(O[C:8](=[O:16])[NH:9][C:10]2[N:15]=[CH:14][CH:13]=[CH:12][N:11]=2)C=CC=CC=1.[N:17]1([CH2:23][C:24]2[CH:25]=[N:26][C:27]3[C:32]([CH:33]=2)=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[N:15]1[CH:14]=[CH:13][CH:12]=[N:11][C:10]=1[NH:9][C:8]([N:20]1[CH2:21][CH2:22][N:17]([CH2:23][C:24]2[CH:25]=[N:26][C:27]3[C:32]([CH:33]=2)=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:18][CH2:19]1)=[O:16]

Komponenten

3

Edukt 2

HCID 232522Phenyl pyrimidin-2-ylcarbamateHCID 578808813-[(Piperazin-1-yl)methyl]quinoline

Produkt 1

HCID 116531644-Quinolin-3-ylmethyl-piperazine-1-carboxylic acid pyrimidin-2-ylamide

Versuchsvorschrift

The title compound was prepared from pyrimidin-2-yl-carbamic acid phenyl ester and 3-piperazin-1-ylmethyl-quinoline in analogy with Example 142. 1H NMR (400 MHz, CDCl3): 8.72 (s, 1H), 8.10-8.02 (m, 1H), 8.43-8.41 (m, 2H), 7.69-7.66 (m, 2H), 7.50-7.40 (m, 2H), 6.82-7.70 (m, 1H), 3.81 (s, 2H), 3.42-3.38 (m, 4H), 2.41-2.36 (m, 4H).

Quellen und Nachweise

ORD-Eintrag
ord-17dd0ace33f440d9ab7c769975c89955
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530476B2

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