Trifluoroacetic acid → HCID 178511743, Verbindung

HRID 406035Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 406035
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC(=O)[NH:14][C@H:15]1[CH2:18][C@H:17]([O:19][C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[N+:27]([O-:29])=[O:28])[CH2:16]1)(C)(C)C>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:26][C:24]1[CH:23]=[CH:22][C:21]([N+:27]([O-:29])=[O:28])=[C:20]([CH:25]=1)[O:19][C@H:17]1[CH2:16][C@H:15]([NH2:14])[CH2:18]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 178454129HCID 178454129, Verbindung

Produkt 1

HCID 178511743HCID 178511743, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

14 ml trifluoroacetic acid were added to a mixture of 2.8 g [trans-3-(5-fluoro-2-nitrophenoxy)-cyclobutyl]-carbamic acid tert-butyl ester in 100 ml methylene chloride at 0° C. The mixture was stirred then for 2 hours at rt and afterwards concentrated. The residue was stirred with diisopropylether and filtered.

Aufarbeitung

  1. concentrationafterwards concentrated
  2. stirringThe residue was stirred with diisopropylether
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-46df0132cbab41f09e6324caffef544c
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754079B2

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