Quinoxaline-2-carbaldehyde → 4-Quinoxalin-2-ylmethyl-piperazine-1-carboxylic acid phenylamide

HRID 40606

Reaktionsgleichung

Reaktionsgleichung von HRID 40606
[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=[CH:18][C:17]=1[CH:26]=O>>[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][N:13]([CH2:26][C:17]3[CH:18]=[N:19][C:20]4[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=4)[N:16]=3)[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

3

Edukt 2

HCID 594088Quinoxaline-2-carbaldehydeHCID 7015289N-phenylpiperazine-1-carboxamide

Produkt 1

HCID 578808524-Quinoxalin-2-ylmethyl-piperazine-1-carboxylic acid phenylamide

Versuchsvorschrift

The title compound was prepared from piperazine-1-carboxylic acid phenylamide and 2-quinoxaline-carboxaldehyde in analogy with Example 18. 1H NMR (400 MHz, CDCl3): 8.96 (s, 1H), 8.06-7.98 (m, 2H), 7.72-7.66 (m, 2H), 7.28-7.16 (m, 4H), 7.96-7.92 (m, 1H), 6.42 (s, 1H), 3.85 (s, 2H), 3.48-3.45 (m, 4H), 3.55-3.52 (m, 4H).

Quellen und Nachweise

ORD-Eintrag
ord-f90e1c69a8914897820afb4dfe013fbf
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530476B2

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