4-Aminobenzoic Acid → 4-[(4-Phenylquinazolin-2-yl)amino]benzoic acid

HRID 406816

Reaktionsgleichung

Reaktionsgleichung von HRID 406816
Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1>CC(O)C>[C:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([NH:18][C:19]3[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=3)[N:11]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

4

Edukt 2

HCID 9784-Aminobenzoic AcidHCID 31235822-Chloro-4-phenylquinazoline

Produkt 1

HCID 7764484-[(4-Phenylquinazolin-2-yl)amino]benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To a solution of 2-chloro-4-phenylquinazoline (9.6 g, 40 mmol) in 2-propanol (130 mL) was added 4-aminobenzoic acid (8.2 g, 60 mmol) and the mixture was stirred at reflux for 4 h. The mixture was cooled to rt and the precipitate was collected by filtration and washed with 2-propanol. The product, 4-(4-phenylquinazolin-2-ylamino)benzoic acid, was isolated as a yellow solid (12.9 g, 95%).

Aufarbeitung

  1. temperatureat reflux for 4 h
  2. filtrationthe precipitate was collected by filtration
  3. washwashed with 2-propanol

Quellen und Nachweise

ORD-Eintrag
ord-47cb96d775a4424a948352d8ce33185e
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754092B2

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