Praziquantel → Praziquanamine

HRID 406932

Reaktionsgleichung

Reaktionsgleichung von HRID 406932
[CH:1]1[CH:2]=[CH:3][C:4]2[CH:10]3[CH2:11][N:12](C(C4CCCCC4)=O)[CH2:13][C:14](=[O:15])[N:9]3[CH2:8][CH2:7][C:5]=2[CH:6]=1.COC(OC)CNCC(NCCC1C=CC=CC=1)=O>>[O:15]=[C:14]1[N:9]2[CH2:8][CH2:7][C:5]3[C:4]([CH:10]2[CH2:11][NH:12][CH2:13]1)=[CH:3][CH:2]=[CH:1][CH:6]=3

Komponenten

3

Edukt 2

HCID 4891PraziquantelHCID 109246802-((2,2-Dimethoxyethyl)amino)-N-(2-phenylethyl)acetamide

Produkt 1

HCID 6453168Praziquanamine

Versuchsvorschrift

Further embodiments disclosed herein provide a process for the preparation of Praziquantel of formula I by cyclisation of 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)acetamide using an acid in the presence of a solvent to obtain 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline; and acylation of 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline with cyclohexanoylchloride in presence of a base and a solvent to obtain Praziquantel.

Aufarbeitung

  1. customFurther embodiments disclosed herein provide a process

Quellen und Nachweise

ORD-Eintrag
ord-5b292083e3c441d79e3c3f9a7a28c18c
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754215B2

Verknüpfte Notizen

Wird geladen…