Hydrochloric Acid → Methyl 3-(6-aminopyridazin-4-yl)benzoate

HRID 407075Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 407075
Cl.C1(C(=[N:15][C:16]2[N:21]=[N:20][CH:19]=[C:18]([C:22]3[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=3)[C:25]([O:27][CH3:28])=[O:26])[CH:17]=2)C2C=CC=CC=2)C=CC=CC=1.C([O-])([O-])=O.[Na+].[Na+]>C1COCC1>[NH2:15][C:16]1[N:21]=[N:20][CH:19]=[C:18]([C:22]2[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=2)[C:25]([O:27][CH3:28])=[O:26])[CH:17]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 86667185Methyl 3-{6-[(diphenylmethylene)amino]pyridazin-4-yl}benzoate

Produkt 1

HCID 67980189Methyl 3-(6-aminopyridazin-4-yl)benzoateAusbeute 218,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1.0 M HCl (2.0 mL) was added to a solution of methyl 3-{6-[(diphenylmethylene)amino]pyridazin-4-yl}benzoate (0.16 g, 0.40 mmol) in THF (4.0 mL) and then the reaction was stirred at r.t. for 1.5 h. The mixture was carefully neutralized with Na2CO3 (2.0 eq) and then concentrated under reduced pressure to give the crude product (0.20 g) which was directly used in the next reaction without further purification. LCMS (M+H)+: m/z=230.1

Aufarbeitung

  1. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ca1d88af2bcf43728a4c01ba018c8fa3
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754114B2

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