Methylamine → HCID 178483385, Verbindung

HRID 407341Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 407341
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 178509116HCID 178509116, Verbindung

Produkt 1

HCID 178483385HCID 178483385, VerbindungAusbeute 32 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

Aufarbeitung

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fca9a3df45314300bb3671d7337b2091
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754233B2

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