Methanol → Methyl azetidine-2-carboxylate hydrochloride

HRID 408610Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 408610
[NH:1]1[CH2:4][CH2:3][CH:2]1[C:5]([OH:7])=[O:6].S(Cl)([Cl:10])=O.[CH3:12]O>>[ClH:10].[CH3:12][O:6][C:5]([CH:2]1[CH2:3][CH2:4][NH:1]1)=[O:7]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 17288Azetidinecarboxylic AcidHCID 24386Thionyl Chloride

Produkt 1

HCID 22476057Methyl azetidine-2-carboxylate hydrochloride

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To a solution of azetidine-2-carboxylic acid (1 eq.) in MeOH at 0° C. was added dropwise thionyl chloride (2.5 eq.). The reaction was stirred at 20° C. for 15 h. The crude was concentrated under reduced pressure and used as such without further purification.

Aufarbeitung

  1. concentrationThe crude was concentrated under reduced pressure
  2. customsuch without further purification

Quellen und Nachweise

ORD-Eintrag
ord-7e083845b2e44d96834f03e73cf5b337
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759334B2

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